Clostridioides difficile

Agencies

Centres for Disease Prevention and Control (CDC)

• About C. Diff (Clostridioides difficile) (2024)

Public Health Agency of Canada (PHAC)

• Clostridium difficile. Infection: Infection Prevention and Control Guidance for Management in Acute Care Settings (2013 update)
• Clostridium difficile: Infection Prevention and Control Guidance for Management in Long-term Care Facilities (2013)

Infectious Diseases Society of America (IDSA) / Society for Healthcare Epidemiology of America (SHEA)

• Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children (2017 update)

United States Agency for Healthcare Research and Quality (AHRQ)

• Early Diagnosis, Prevention, and Treatment of Clostridium difficile: Update (2016)

Professional societies

American College of Gastroenterology (ACG)

• ACG Clinical Guidelines: Prevention, Diagnosis, and Treatment of Clostridioides difficile Infections (2021)

Australian Infection Control Association

• ASID/AICA position statement – Infection control guidelines for patients with Clostridium difficile infection in healthcare settings (2011)

European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for C. difficile (ESGCD)

• 2021 update on the treatment guidance document for Clostridium difficile infection (CDI) (2021)
• Guidance document for prevention of Clostridium difficile infection in acute healthcare settings (2018)

Infectious Diseases Society of America (IDSA)

• Clinical Practice Guideline by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA): 2021 Focused Update Guidelines on Management of Clostridioides difficile Infection in Adults (2021)

International Society for Infectious Diseases

• Guide to infection control in the healthcare setting - Bacterial Enteric Pathogens: Clostridioides difficile, Salmonella, Shigella, Escherichia coli, and others (2018)

Society for Healthcare Epidemiology of America (SHEA)

• Strategies to prevent Clostridioides difficile infections in acute-care hospitals: 2022 Update (2022)

Spanish Society of Chemotherapy (SEC)

• Recommendations for the diagnosis and treatment of Clostridioides difficile infection: An official clinical practice guideline of the Spanish Society of Chemotherapy (SEQ), Spanish Society of Internal Medicine (SEMI) and the working group of Postoperative Infection of the Spanish Society of Anesthesia and Reanimation (SEDAR)

EU/EEA countries

Austria

• Clostridium-difficile-Infektionen (CDI) (C. difficile-assoziierte Erkrankung, CDAD) (2025)

Belgium

• Clostridium difficile (2017)

Cyprus

• ΠΡΟΛΗΨΗ ΚΑΙ EΛΕΓΧΟΣ ΛΟΙΜΩΞΗΣ ΑΠΟ CLOSTRIDIOIDES DIFFICILE ΣΕ ΧΩΡΟΥΣ ΠΑΡΟΧΗΣ ΥΠΗΡΕΣΙΩΝ ΥΓΕΙΑΣ (2025)

Czechia

• Doporučený postup diagnostiky a léčby kolitidy vyvolané Clostridium difficile (2014)

Finland

• Suositus hoitoon liittyvien Clostridioides difficile -infektioiden torjuntaan (2023)

France

• Relatif à la maîtrise de la diffusion des infections à Clostridium difficile dans les établissements de santé français (2006)

Germany

• Hygienemaßnahmen bei Clostridioides difficile-Infektion (CDI)

Hungary

• Módszertani levél a Clostridium difficile fertőzések diagnosztikájáról, terápiájáról és megelőzéséről (2. átdolgozott kiadás)

Ireland

• Surveillance, Diagnosis and Management of Clostridium difficile Infection in Ireland (2014)

Italy

• Prevention and control of Clostridium difficile infections (Italian Multidisciplinary Society for the Prevention of Infections in Healthcare settings, 2009)
  Prevenzione e controllo delle infezioni da Clostridium difficile (Società Italiana Multidisciplinare per la Prevenzione delle Infezioni nelle Organizzazioni Sanitarie, 2009)

Netherlands

• Clostridioides difficile (2024)

Norway

• Clostridium difficile: guidelines for healthcare personnel (Norwegian Public Health Institute, 2015)
  Clostridium difficile-infeksjon - veileder for helsepersonel (Folkehelseinstituttet, 2015)
• Clostridioides difficile (Clostridium difficile)-infeksjon - håndbok for helsepersonell (2023)

Poland

• Zakażenia Clostridioides (Clostridium) difficile: epidemiologia, diagnostyka, terapia, profilaktyka (2018)

Portuguese

• Norma nº 019/2014 atualizada a 24/03/2015 Diagnóstico da Infeção por Clostridium difficile nos Hospitais, Unidades de Internamento de Cuidados Continuados Integrados e na Comunidade (2015)

Romania

• Ghiduri si protocoale

Slovakia

• Odporúčaný postup diagnostiky a liečby kolitídy spôsobenej Clostridium difficile (2015)

Slovenia

• Professional basis and guidelines for the control and prevention of healthcare-associated infections (2009)

Spain

• Recomendaciones sobre precauciones estándar y precauciones basadas en la transmisión de microorganismos (2017)

Sweden

• Clostridium difficile infections: Knowledge base and recommendations for monitoring, prevention and outbreaks (National Public Health Institute, 2017)
  Clostridium difficile-infektion: Kunskapsunderlag och rekommendationer för övervakning, prevention och utbrottshantering (Folkhälsomyndighetens, 2017)

Countries outside of the EU/EEA

Australia

• Clostridioides difficile Infection Prevention and Control (Queensland Health, 2020)

United Kingdom

• Clostridioides difficile infection Updated guidance on management and treatment (United Kingdom Health Security Agency, 2022)
• Clostridioides difficile infection: antimicrobial prescribing (NICE, 2021)

South Africa

• South African Society of Clinical Microbiology Clostridioides difficile infection diagnosis, management and infection prevention and control guideline (South African Society of Clinical Microbiology, 2020)