Failure of adolescent booster responses to tetanus toxoid despite infant immunization.
The aim of this study was to assess the capacity of a tetanus toxoid booster to reactivate infant-triggered immunity.
Posfav-Barbea et al. – June 2010 – Vaccine 2010; 28: 4356-4361. Frequent failure of adolescent booster responses to tetanus toxoid despite infant immunization: Waning of infant-induced immune memory
The aim of this study was to assess the capacity of a tetanus toxoid booster to reactivate infant-triggered immunity. To define that, anti-tetanus antibodies were assessed before and after boosting 162 adolescents and 219 children from Mfou (Cameroon). Among 63 adolescents with 3 recorded dose of infant DTP, 29/63 (46%) responded with a ≥4-fold increase of antibody titers, 35/63 (55%) reaching the 0.10 UI/ml threshold. Response rates were slightly higher (62%) in children aged 10–11 years. Responders and non-responders only differed significantly in their baseline anti-tetanus antibodies.
Disclosure statement: The study was supported by Children Action, a charitable foundation for disadvantaged children throughout the world, and by university research funds of the WHO Collaborating Center for Neonatal Vaccinology. Two of the authors have received honoraria and research grants from various vaccine manufacturers, but none related to this work. All other authors declared no conflict of interest.
ECDC comment, 7 June 2010: This study demonstrates that infant immunization in absence of childhood boosting does not result in the long-term persistence of anti-TT immune memory. This result supports the WHO recommendation to implement childhood and adolescence DTP boosters.
Immunity to tetanus and diphtheria in the UK in 2009.
19 Dec 2012 - These UK data indicate immunity gaps to tetanus and diphtheria in the very young, those aged 10-11 years and in the oldest.
Risk of febrile seizures and epilepsy after vaccination with diphtheria, tetanus, acellular pertussis, inactivated poliovirus, and Haemophilus influenzae type B
28 Mar 2012 - This study, strong of an almost complete follow-up of all children born in Denmark from 2003 to 2008, provides evidence that the DTaP-IPV-HiB vaccine is not associated to an overall increased risk of febrile seizures and epilepsy.
Post-licensure comparison of the safety profile of diphtheria/tetanus/whole cell pertussis/haemophilus influenza type b vaccine and a 5-in-1 diphtheria/tetanus/acellular pertussis/haemophilus influenza type b/polio vaccine in the United Kingdom
28 Oct 2010 - In this paper, the General Practice Research Database (GPRD) was used to compare the reactogenicity in infants of a 5-in-1 acellular pertussis vaccine (DTaP5/Hib/IPV) introduced in the United Kingdom in 2004 to the 4-in-1 whole cell-pertussis vaccine (DTwP/Hib) that it replaced.