ECDC/EFSA/EMA first joint report on the integrated analysis of the consumption of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from humans and food-producing animals
Joint Interagency Antimicrobial Consumption and Resistance Analysis (JIACRA) ReportThe ECDC, the EFSA and the EMA have for the first time jointly explored associations between consumption of antimicrobials in humans and food-producing animals, and antimicrobial resistance in bacteria from humans and food-producing animals, using 2011 and 2012 data currently available from their relevant five EU monitoring networks.
A summary indicator of the proportion of resistant bacteria in the main food-producing animal species was calculated for the analysis, as consumption data in food-producing animals were not available at the species level. Comparison of antimicrobial consumption data in animals and humans in 2012, both expressed in milligrams per kilogram of estimated biomass, revealed that overall antimicrobial consumption was higher in animals than in humans, although contrasting situations were observed between countries.
The consumption of several antimicrobials extensively used in animal husbandry was higher in animals than in humans, while consumption of antimicrobials critically important for human medicine (such as fluoroquinolones and 3rd-and 4th-generation cephalosporins) was higher in humans. In both humans and animals, positive associations between consumption of antimicrobials and the corresponding resistance in bacteria were observed for most of the combinations investigated. In some cases, a positive association was also found between antimicrobial consumption in animals and resistance in bacteria from humans. While highlighting findings of concern, these results should be interpreted with caution owing to current data limitations and the complexity of the AMR phenomenon, which is influenced by several factors besides antimicrobial consumption. Recommendations to address current data limitations for analyses of this type were identified. In any case, responsible use of antimicrobials in both humans and animals should be promoted.
Antimicrobial consumption - Annual Epidemiological Report for 2017
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Surveillance of antimicrobial resistance in Europe 2017
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Gonococcal antimicrobial susceptibility surveillance in Europe, 2016
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