Public health guidance on use of interferon-gamma release assays in support of TB diagnosis
This report sets out the evidence on IGRAs and their use in the diagnosis of latent and active tuberculosis.After reviewing all available evidence, the expert panel concluded that ‘IGRAs should not replace the standard diagnostic methods for diagnosing active TB.’
Mastering the basics of TB control – Development of a handbook on TB diagnostic methods
This handbook consists of nine chapters describing basic techniques in the laboratory diagnosis of tuberculosis.
Risk assessment: Laboratory-created A(H5N1) viruses transmissible between ferrets
The results of two, as yet unpublished, investigations of laboratory-induced genetic changes in avian influenza A(H5N1) viruses have been reported to have found that a surprisingly few number of changes make the viruses transmissible between ferrets, the most commonly used model for the way influenza behaves in humans. The possibility that this could have resulted in the development in laboratories of A(H5N1) influenza viruses transmissible between humans has caused concern for public safety and generated unusually high levels of debate in the scientific community. This report summarises and explains the complex public health and scientific issues around these developments including the positive and negative aspects of some of the responses that have been proposed internationally.
CNRL in silico exercise to determine the capabilities of network laboratories to detect triple reassortant swine origin influenza A(H3N2) viruses
Following the emergence of swine influenza A(H3N2) variant (v) viruses with sporadic human infections in North America, the Community Network of Reference Laboratories (CNRL) and the Animal Health and Veterinary Laboratories Agency completed an exercise to assess the CNRL’s capability to detect novel reassortant and circulating triple reassortant swine viruses (TRA) in humans.
Influenza A(H3N2)v laboratory detection questionnaire results
Following the emergence of swine influenza A(H3N2) variant (v) viruses with sporadic human infections in North America, ECDC and the Community Network of Reference Laboratories (CNRL) disseminated a questionnaire to explore the RT-PCR capability of influenza reference laboratories in EU/EEA countries to detect A(H3N2)v viruses in their day-to-day diagnostics and to subtype them as swine-origin variant viruses.
Influenza virus characterisation - Summary Europe, June 2012
The latest issue of ECDC’s series of technical documents on 'Influenza virus characterisation’ covers the time period from January 2012 to June 2012.
External quality assessment scheme for antiviral susceptibility detection in influenza viruses
The first European external quality assessment exercise for antiviral susceptibility detection in influenza viruses was carried out during winter 2010/11. Twenty laboratories from 16 European countries participated in the exercise.
Evaluation of influenza virus antiviral susceptibility testing in Europe: Results from the first external quality assessment exercise
Thompson, C.I., Lackenby, A., Daniels, R.S., McCauley, J.W., Pereyaslov, D., Broberg, E.K., Meijer, A., Zambon, M.C.,