Despite good access to effective antibiotics, Streptococcus pneumoniae (pneumococci) is still a major cause of disease and death in both developing and developed countries. Pneumococci are the main cause of bacterial respiratory tract infections, such as pneumonia, middle ear infection, and sinusitis, in all age groups.
Haemophilus influenzae type b (Hib) is an obligate human pathogen and an important cause of invasive bacterial infections in both children and adults, with the highest incidence among young children.
The transmission of Clostridioides difficile can be patient-to-patient, via contaminated hands of healthcare workers or by environmental contamination.
HIV is a virus which attacks the immune system and causes a lifelong severe illness with a long incubation period. The end-stage of the infection, acquired immunodeficiency syndrome (AIDS), results from the destruction of the immune system.
Severe acute respiratory syndrome (SARS) is a life-threatening respiratory disease caused by a recently identified coronavirus; the SARS-associated coronavirus (SARS-CoV). This is believed to be an animal virus that recently crossed the species barrier to infect humans.