The transmission of Clostridioides difficile can be patient-to-patient, via contaminated hands of healthcare workers or by environmental contamination.
Cholera is an acute diarrhoeal infection caused by the bacterium Vibrio cholera of serogroups O1 or O139. Humans are the only relevant reservoir, even though Vibrios can survive for a long time in coastal waters contaminated by human excreta.
Diphtheria is spread through droplets from coughing or sneezing. Most often the disease causes a sore throat and low grade fever in the first few days of the illness.