Risk of febrile seizures and epilepsy after vaccination with diphtheria, tetanus, acellular pertussis, inactivated poliovirus, and Haemophilus influenzae type BArchived

ECDC comment

​This study, strong of an almost complete follow-up of all children born in Denmark from 2003 to 2008, provides evidence that the DTaP-IPV-HiB vaccine is not associated to an overall increased risk of febrile seizures and epilepsy. The results of this study are therefore extremely useful to support the promotion of the DTaP-IBV-HiB and to reassure the public opinion on the safety profile of the new vaccine.

Sun Y, Christensen J, Hviid A, Li J, Vedsted P, Olsen J, Vestergaard M. JAMA. 2012 Feb 22;307(8):823-31.

Public awareness of possible adverse effects following whole-cell pertussis vaccination has caused in the past years a reduction in immunization rates and outbreaks of whooping cough in several countries.

This study, strong of an almost complete follow-up of all children born in Denmark from 2003 to 2008, provides evidence that the DTaP-IPV-HiB vaccine is not associated to an overall increased risk of febrile seizures and epilepsy. The results of this study are therefore extremely useful to support the promotion of the DTaP-IBV-HiB and to reassure the public opinion on the safety profile of the new vaccine.