Seroprevalence of Measles-, Mumps- and Rubella-Specific IgG Antibodies in German Children and Adolescents and Predictors for SeronegativityArchived
This large population based sero-epidemiological study describes MMR seroprevalence as a whole and calculates independent predictors for seronegativity for measles, mumps and rubella antibodies in Germany. This large population based sero-epidemiological study describes MMR seroprevalence as a whole and calculates independent predictors for seronegativity for measles, mumps and rubella antibodies in Germany.
Poethko-Muller C, Mankertz A (2012) PLoS ONE 7(8): e42867. doi:10.1371/journal.pone.0042867
This large population based sero-epidemiological study describes MMR seroprevalence as a whole and calculates independent predictors for seronegativity for measles, mumps and rubella antibodies in Germany.
Seronegativity was above the overall WHO target level of 5% in children who had received a single dose vaccination, however, the target level was met, for measles and rubella, in those who had received two doses of measles vaccine. Seronegativity increased as well by years since last vaccination thus indicating antibody waning for measles, mumps and rubella.
This study supports and confirms once again the crucial importance of a two-dose vaccination schedule to achieve measles and rubella elimination and to control mumps outbreaks.