Accelerating Control of Pertussis in England and WalesArchived
Despite a reduction in pertussis among younger children and infants, rates of pertussis-related sickness and death remain high compared with rates for other vaccine-preventable diseases in England and Wales. Pertussis control is still far from optimal, and, as in other industrialised countries, the disease continues predominantly in young infants and in teenagers and adults, in whom immunity may have waned.
Campbell H, Amirthalingam G, Andrews N, Fry NK, George RC, Harrison TG, Miller E. Emerg Infect Dis. 2012 Jan;18(1):38-47. doi: 10.3201/eid1801.110784.
This raises two major policy issues: how to better protect vulnerable infants and whether pertussis in teenagers and adults warrants targeted prevention. Future vaccine program changes should take these issues in consideration, although more information and scientific evidence are required to inform such decisions.
Pertactin-Negative Variants of Bordetella pertussis in the United States
11 Feb 2013 - This letter to the editor raises the issue of the adaptation of B. pertussis to vaccine selection pressure as one of the reasons for the increase number of cases of whooping cough reported in several countries.
Waning Protection after Fifth Dose of Acellular Pertussis Vaccine in ChildrenArchived
24 Sep 2012 - The authors assess the risk of pertussis in children in California relative to the time since the fifth dose of DTaP from 2006 to 2011 (this period included a large outbreak in 2010).
Risk of febrile seizures and epilepsy after vaccination with diphtheria, tetanus, acellular pertussis, inactivated poliovirus, and Haemophilus influenzae type BArchived
28 Mar 2012 - This study, strong of an almost complete follow-up of all children born in Denmark from 2003 to 2008, provides evidence that the DTaP-IPV-HiB vaccine is not associated to an overall increased risk of febrile seizures and epilepsy.