Influenza vaccine effectiveness
To establish how well influenza vaccines work each season, influenza vaccine effectiveness is measured in observational studies. Vaccine effectiveness is an estimate of the likelihood that a vaccine prevents influenza infection when used in everyday practice.
In Europe influenza vaccine effectiveness studies were initiated by ECDC and have been followed systematically since the influenza season 2008/2009 by a network of public health and academic researchers (I-MOVE). Results have been provided for inactivated influenza vaccines overall with no possibility to distinguish between different vaccine products. However, results have been presented by age group and by different influenza vaccine strain. In general, a vaccine effectiveness of ~30-60% has been estimated for the three different influenza A (H1N1, H3N2) and B strains (Victoria or Yamagata lineages). Since the influenza season 2012/13 results from observational studies assessing also LAIV used in children have been published.
Table: Overview of articles on effectiveness of inactivated seasonal influenza vaccines estimated in multi-center studies conducted by the I-MOVE network in Europe
The live attenuated influenza vaccines used in paediatric programmes in Finland, Germany and United Kingdom have also been evaluated:
All ECDC updates on vaccine effectiveness and efficacy
Annual influenza vaccine effectiveness meeting 2013 – summary of discussions on obtained results and recommended future research focus
ECDC Study protocols for influenza vaccine effectiveness studies
Protocols for case-control studies to measure influenza vaccine effectiveness in the EU and EEA Member States
17 Nov 2009 - This publication presents the core European protocol for a series of proposed influenza vaccine effectiveness studies. The protocol includes a proposed plan for pooled analysis and has recently been adapted to measure vaccine effectiveness for the pandemic vaccine in 2009-10. Together with its twin publication ‘Protocols for cohort database studies to measure influenza vaccine effectiveness in the EU and EEA Member States’, this publication covers all methodological issues in the design and implementation of vaccine effectiveness studies, both for seasonal and the new A(H1N1)v influenza.
Protocols for cohort database studies to measure influenza vaccine effectiveness in the EU and EEA Member States
17 Nov 2009 -